release 3
Dec.31.2015 |
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- added filtering of gappy alignment members, and retention of high sequence similarity members
- reduced filtering of alignments for size (allowed higher limit on sequence count)
- replaced java applet structure viewer (Jmol) with webGL based viewer (3Dmol)
- added Web API access to alignment based specificity and conservation column scores
- added JSON format output for Web APIs
- updated to Pfam 27, Mar 2013 –– 14831 families
- updated to PDB of Aug.22.2014 –– 102863 structures
- updated to Uniprot 2014_07 –– 140303 human sequences (Swissprot+Trembl)
- updated mappings to RefSeq release 67 (64712 mapped isoforms) / hg19 (NCBI GRCh37)
- added mappings to RefSeq release 70 (94341 mapped isoforms) / hg38 (NCBI GRCh38)
| release 2
Sep.12.2012 |
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- all missense variants in reference genome pre-computed, use front page links to download tables
- better genomic coverage (some positions at exon-junction codons were missing in release 1)
- updated to Pfam 26, Nov 2011 –– 13672 families
- updated to PDB of Jul.13.2012 –– 83106 structures
- updated to Uniprot 2012_07 –– 91597 human sequences (Swissprot+Trembl)
- updated to RefSeq release 54 –– 32116 isoforms
- NCBI build 37 version 3
| version 1.0
Sep.08.2011 |
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- updated to Pfam 25, March 2011 –– 12273 families
- updated to PDB of Aug.02.2011 –– 74732 structures
- updated to Uniprot 2011_05 –– 105805 human sequences (Swissprot+Trembl)
- Human Genome build 19 (NCBI 37) supported
- output columns added "Reference Genome Variant", "Reference Genome Variant Type"
(missense, silent, stop loss, stop codon) - applicable to variants submitted in genomic coordinates
| version 0.75
Jan.27.2010 |
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- updated to Pfam 24, Oct.2009 –– 11912 families
- updated to PDB of Dec.22.2009 –– 62306 structures
- updated to Uniprot 15.12 of Dec.15.2009 –– 96123 human sequences (Swissprot+Trembl)
- variants in genomic coordinates now supported (HG build 18)
- fixed all errors in binding sites annotations!
- fixed issues with 'Interacts with tumor suppresors', 'Interacts with oncogenes'
- structure in Jmol now centered on variant residue
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Computational Biology Center | Memorial Sloan Kettering Cancer Center
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