functional impact of protein mutations
release   3  

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Method and server white paper (PDF) (based on data for very first release v0.75 beta)

Reva B, Antipin Y, Sander C. Nucleic Acids Research (2011)
"Predicting the Functional Impact of Protein Mutations: Application to Cancer Genomics"

The method is based on earlier publication:

Reva, B.A., Antipin, Y.A. and Sander, C. (2007) Genome Biol, 8, R232.
"Determinants of protein function revealed by combinatorial entropy optimization"


MutationAssessor was used by these projects:

The Cancer Genome Atlas Research Network. Nature (2011)
"Integrated Genomic Analyses of Ovarian Carcinoma"

The Cancer Genome Atlas Network. Nature (2008)
"Comprehensive genomic characterization defines human glioblastoma genes and core pathways"

Taylor et al. Cancer Cell (2010)
"Integrative genomic profiling of human prostate cancer"

Barretina et al. Nature Genetics (2010)
"Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy"

Computational Biology Center | Memorial Sloan Kettering Cancer Center